Researchers close to Alzheimer's blood test
Australian researchers are inching closer to being able to conduct a blood test to for the early detection of Alzheimer’s disease thanks to a breakthrough by a CSRIO team.
The team of researchers from the CSIRO discovered blood-based biological markers that are associated with the build up of a toxic protein which occurs years before the onset of symptoms on the disease.
Dr Samantha Burnham, from CSIRO’s Preventative Health Flagship, said that the breakthrough is a crucial step in countering the disease, which is the leading cause of dementia in Australia.
"Early detection is critical if we are to make any real difference in the battle against Alzheimer's, giving those at risk a much better chance of receiving treatment earlier, before it’s too late to do much about it," said Dr Burnham.
Currently, about one quarter of a million Australians suffer from dementia, with that figure expected to increase to one million by 2050.
Sophisticated mathematical models were used to analyse data from 273 participants in the Australian Imaging, Biomarkers and Lifestyle study of ageing (AIBL).
This identified nine markers that correlate with brain positron emission tomography (PET) imaging measurements of a toxic protein, amyloid beta, which deposits in the brain as plaques early in disease development.
"The progressive build up of the toxic protein, amyloid beta, is one of the earliest changes in the brain associated with the development of Alzheimer's disease," said Dr Noel Faux, from the Florey Institute for Neuroscience and Mental Health.
"A recent study from the AIBL team showed that amyloid beta levels become abnormal about 17 years before dementia symptoms appear. This gives us a much longer time to intervene to try to slow disease progression if we are able to detect cases early."
Dr Burnham adds “We hope our continued research will lead to the development of a low cost, minimally invasive population based screening test for Alzheimer’s."
"A blood test would be the ideal first stage to help identify many more people at risk before a diagnosis is confirmed with cognitive tests and PET imaging or cerebral spinal fluid (CSF) testing."