Plans up for 3D-printed phone 'scope
Australian researchers have developed a 3D printable clip-on that can turn any smartphone into a microscope.
The smartphone microscope is powerful enough to visualise specimens as small as 1/200th of a millimetre, including microscopic organisms, animal and plant cells, blood cells, cell nuclei and more.
The clip-on technology is unique in that it requires no external power or light source to work yet offers high-powered microscopic performance in a robust and mobile handheld package.
The researchers behind it - from the ARC Centre of Excellence for Nanoscale BioPhotonics (CNBP) and RMIT University - are making the technology freely available, sharing the 3D printing files publicly so that anyone can turn their own smartphones into microscopes.
The technology has immense potential as a scientific tool, especially for use in remote areas and for field-work where larger standalone microscopes are unavailable or impractical.
“We’ve designed a simple mobile phone microscope that takes advantage of the integrated illumination available with nearly all smartphone cameras,“ says lead developer and CNBP Research Fellow at RMIT University, Dr Antony Orth.
The clip-on has been engineered with internal illumination tunnels that guide light from the camera flash to illuminate the sample from behind. This overcomes issues seen with other microscopy-enabled mobile phone devices, Dr Orth says.
“Almost all other phone-based microscopes use externally powered light sources while there’s a perfectly good flash on the phone itself,” he explains.
“External LEDs and power sources can make these other systems surprisingly complex, bulky and difficult to assemble.”
“The beauty of our design is that the microscope is useable after one simple assembly step and requires no additional illumination optics, reducing significantly the cost and complexity of assembly. The clip-on is also able to be 3D printed making the device accessible to anyone with basic 3D printing capabilities.”
The clip-on also enables both bright-field and dark-field microscopy techniques. Bright-field microscopy is where a specimen is observed on a bright background. Conversely, dark-field shows the specimen illuminated on a dark background.
“The added dark-field functionality lets us observe samples that are nearly invisible under conventional bright-field operation such as cells in media,” Dr Orth says.
“Having both capabilities in such a small device is extremely beneficial and increases the range of activity that the microscope can be successfully used for.”
Dr Orth believes the potential applications for the smartphone microscope are enormous.
“Our mobile microscope can be used as an inexpensive and portable tool for all types of on-site or remote area monitoring.”
“Water quality, blood samples, environmental observation, early disease detection and diagnosis—these are all areas where our technology can be easily used to good effect.”
It could also benefit developing countries.
“Powerful microscopes can be few and far between in some regions,” says Dr Orth.
“They’re often only found in larger population centres and not in remote or smaller communities. Yet their use in these areas can be essential—for determining water quality for drinking, through to analysing blood samples for parasites, or for disease diagnosis including malaria.”
The 3D printing files for the microscope clip-on are available for download at the CNBP web site.
More details are available in a research paper on the device.