Parents all important, from the first moment it starts
Parents play the major role in the future health of their children, but new research shows even the exact moment of conception can influence a kid's fate.
It turns out that quality and content of the semen impacts the chances of successful sperm developing obesity, diabetes, and other metabolic health conditions.
Researchers at the University of Adelaide's Robinson Institute have been studying the complex interactions between male seminal fluid and female reproductive tissues, with new findings now published in the Proceedings of the National Academy of Science (PNAS).
“We know from several studies that obesity in males can be tracked back to the father's contribution at the moment of conception,” says Professor Sarah Robertson, research leader and Director of the Robinson Institute at the University of Adelaide
“But now we're starting to understand the very complex signals and information being transmitted by the seminal fluid, and it turns out that seminal fluid and female tissues interact in surprising ways.”
“We've discovered that it's not just the sperm, but the entire composition of the seminal fluid which has an important role to play in establishing the offspring's future health, and this is most notably seen in male offspring.
“If the seminal fluid is of poor quality, it affects the female's capacity to support an embryo,” Prof Robertson said.
“If the embryo manages to survive despite the poor quality seminal fluid, the metabolism of the resulting foetus will be permanently altered, making it more likely to develop a syndrome of metabolic disorders including obesity, high blood pressure and glucose intolerance after birth,” she says.
Seminal fluid contains signals which trigger production of proteins in the female reproductive tract, the balance between proteins which promote embryo survival and those which cause embryo demise are changed according to the signals present in seminal fluid.
Professor Robertson says this new understanding of the role of seminal fluid could lead to better advice and new options for infertile couples.
“It's clear to us now that the seminal fluid produces signals that the embryo absolutely needs for the best possible start to life. Assisted reproductive techniques, as good as they are today, cannot currently replicate such complexity. Therefore, it's helpful if we can find other ways to encourage couples to take care of their reproductive health, including men as well as women.” Professor Robertson says.
The research was funded by the National Health and Medical Research Council (NHMRC) of Australia.