Groups reach vaccine agreement
A new partnership aims to supercharge the development of new vaccines.
The $14.7 million Coalition for Epidemic Preparedness Innovations (CEPI) has funded a research consortium to develop a rapid response pipeline to develop and test new vaccines in as little as 16 weeks.
The partnership will use technology developed at The University of Queensland, and will be led by UQ’s Professor Paul Young and Dr Keith Chappell.
“The World Health Organization’s Blueprint list of priority diseases recognises that new epidemics can arise from known and unknown viruses – the latter referred to as ‘Disease X’,” Professor Young says.
“These new and emerging pathogens have the potential to reach global epidemic levels.”
Dr Chappell said the project was ambitious, as more conventional approaches could take years or even decades.
“We aim to be able to manufacture more than 200,000 doses of a new vaccine, demonstrate safety and the likelihood of efficacy, and be ready for field deployment in as little as six months.”
Professor Young, Dr Chappell and Dr Daniel Watterson have patented ‘molecular clamp’ technology that provides stability to the viral proteins that are the primary target of our immune defence.
“The technology has been designed as a platform approach to generate vaccines against a range of human and animal viruses,” Professor Young said.
“We’ve had some extremely promising results so far from trials targeting viruses such as influenza, Ebola, Nipah and MERS coronavirus.”
Dr Watterson said the collaboration would act as an insurance policy against deadly outbreaks caused by the emergence of viral epidemics or pandemics.
“By rapidly creating vaccines to these new threats, we’ll be able to quickly limit the spread of disease and diffuse potentially catastrophic situations.
“Molecular clamp technology has the potential to address some of today’s most devastating diseases and to fundamentally change how we protect ourselves from common diseases.”
The collaboration involves UQ, the CSIRO, the World Health Organization’s Collaborating Centre for Reference and Research on Influenza (WHO-CC), the Australian National University (ANU), Hong Kong University (HKU) and Q-Pharm Pty Ltd.