AgResearch (View other jobs from this organisation)
http://www.researchcareer.com.au/
The Organisation
AgResearch is a leading Crown Research Institute charged with delivering science and innovation to benefit New Zealand agriculture and its wider economy. Our internationally recognised scientists are dedicated to this mission and we collaborate with world leading science organisations and universities to achieve exceptional science delivery. We are proud to be unique organisation that is driving prosperity by transforming agriculture to better equip our future generations to come.
The Role
Identifying key molecular triggers that transform bacteria from “good to bad” is critical to understand and control inter-conversion between beneficial and harmful properties. Our research has found two phylogenetically similar strains of Lactobacillus fermentum which have contrasting effects on intestinal epithelial barrier integrity. One strain, AGR1485, was found to maintain the barrier integrity of cultured human epithelial colorectal adenocarcinoma Caco-2 cell monolayers, while the other, AGR1487, decreased the integrity. A healthy intestinal barrier is essential to preventing unwanted components entering our body and causing inflammatory and autoimmune diseases.
We are seeking an outstanding PhD candidate to undertake research to determine the genetic mechanisms responsible for the different effects of the two L. fermentum strains. Initial comparative analyses of draft genome sequences reveal that the strains have highly similar gene contents. However, a small number of loci have been found in AGR1487 but not AGR1485. These strains provides a unique opportunity to understand how the difference of a few factors may impact the health of the host, and how its manipulation can radically alter the balance of host microbial interactions. Using comparative genomics analyses, RNA sequencing, and site directed mutagenesis, the student will elucidate mechanisms that determine how phylogenetically similar strains can have markedly different effects and further the knowledge of Lactobacillus genome biology and its interactions with the health of the host.
Duties
About you
Benefits
The three year studentships includes an annual tax-free stipend of NZD30,000 plus tuition fees and consumables. The research will be undertaken within the Food Nutrition & Health team at AgResearch Grasslands in Palmerston North, New Zealand. The project is funded by the Riddet Centre of Research Excellence and the student will be enrolled at Massey University in Palmerston North
How to apply
Closing date for applications is 31 August 2016
Please apply online via https://careers.sciencenewzealand.org/jobdetails/ajid/oWMV7/PhD-Student-Jekyll-and-Hyde-when-good-bacteria-turn-bad,18470.html or contact Associate Prof Nicole on +64-6-351-8110 for a confidential discussion.