First listed on: 23 July 2021

Bioconjugation Chemistry Research Scientist


The Opportunity

  • Apply organic chemistry, bioconjugation chemistry, protein and polymer chemistry to prepare compounds and materials
  • Use your bioconjugation chemistry expertise to explore innovative new areas of science
  • Diverse and inclusive culture. Flexible work arrangements!

CSIRO’s Manufacturing Business Unit brings together multi-disciplinary scientific and engineering capabilities using world-class infrastructure to partner with industry in order to develop innovative products and processes to allow Australian manufacturers to be globally competitive and environmentally sustainable. The Biomedical Manufacturing Research Program works with biomedical companies to deliver new medical treatments and technologies that benefit millions of people in Australia and overseas, helping them live longer, healthier, and more productive lives.

As a research scientist in bioconjugation chemistry, you will use your expertise in synthetic organic chemistry, antibody bioconjugation, protein modification and protein purification, polymer chemistry, bioconjugation of small molecules and polymers to proteins, conjugation of small molecules to polymers, and polymer-protein conjugates. You will contribute to a wide range of bioconjugation projects. This is a great opportunity to develop a state-of-the-art research program within CSIRO's Manufacturing business unit, building innovation within chemical biology and bioconjugation techniques. 

Your duties will include:

  • Under the direction of senior research scientists, carry out innovative, impactful research of strategic importance to CSIRO that will, where possible, lead to novel and important scientific outcomes. 
  • Apply bioconjugation chemistry techniques to new areas of science as guided by client projects and the strategic direction of the BU.  
  • Apply organic chemistry, bioconjugation chemistry, protein and polymer chemistry to prepare compounds and materials as required to deliver upon the research goals of the BU, including for clients.  
  • Apply novel bioconjugation chemistry and protein chemistry for covalent attachment of functional small molecules, at a pre-defined site on a protein. Develop methods to analyse the conjugate for determination of the site and number of functional small molecules attached. 
  • Apply bioconjugation chemistry to a range of polymers to install small molecules as needed by clients or for internal strategic project development.  
  • Contribute to the development of innovative concepts and new ideas to further bioconjugation chemistry research within the BU.  
  • Under limited direction, assist in the planning and preparation of research proposals and carry out research investigations, requiring originality, creativity and innovation.  

Location: Clayton, Melbourne
Salary: AU$100k – AU$108k plus up to 15.4% superannuation
Tenure: Indefinite
Reference: 75641

To be considered you will need:

  • A PhD in a relevant discipline such as chemistry, with experience in protein chemistry and conjugation, and postdoctoral or industry experience using/developing bioconjugation chemistry techniques.  
  • High level written and oral communication skills with the ability to represent the research team effectively internally and externally, including at national and international conferences, and a record of publications in quality, peer reviewed journals. 
  • Demonstrated expertise in synthetic chemistry including the ability to perform labelling of proteins or antibodies and ability to perform protein chemistry, purification, and analysis. 
  • Proven ability to perform conjugation of small molecules and proteins to polymers, including purification and analysis methods.  
  • The ability to work effectively as part of a multi-disciplinary, regionally dispersed research team, plus the motivation and discipline to carry out autonomous research. 
  • A record of science innovation and creativity, plus the ability & willingness to incorporate novel ideas and approaches into scientific investigations. 
  • Experience with synthetic polymer chemistry, enzyme cascade reactions, biocatalysis, and enzyme assays is desirable, as is working knowledge of surface chemistry especially as applied to flow chemistry and a general understanding of GMP manufacturing requirements.  

For full details about this role please review the Position Description


The successful applicant will be required to obtain and provide a National Police Check or equivalent.

Flexible Working Arrangements

We work flexibly at CSIRO, offering a range of options for how, when and where you work. 

Diversity and Inclusion

We are working hard to recruit people representing the diversity across our society, and ensure that all our people feel supported to do their best work and feel empowered to let their ideas flourish. 


At CSIRO Australia's national science agency, we solve the greatest challenges through innovative science and technology. We put the safety and wellbeing of our people above all else and earn trust everywhere because we only deal in facts. We collaborate widely and generously and deliver solutions with real impact. 

Join us and start creating tomorrow today!

How to Apply

Please apply on-line and provide a cover letter and CV that best demonstrate your motivation and ability to meet the requirements of this role.

Applications Close

22 August 2021, 11:00pm AEST

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